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Article

Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas.

The American journal of pathology - 1 Aug 2000

La Perle K M, Jhiang S M, Capen C C

Abstract excerpt

Papillary thyroid carcinomas in humans are associated with the ret/PTC oncogene and, following loss of p53 function, may progress to anaplastic carcinomas. Mice with thyroid-targeted expression of ret/PTC1 developed papillary thyroid carcinomas that were minimally invasive and did not metastasize. These mice were crossed with p53-/- mice to investigate whether loss of p53 would promote anaplasia and metastasis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10934169
DOI: 10.1016/S0002-9440(10)64577-4
PMCID: PMC1850128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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