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Article

Thyroid hormone receptors are tumor suppressors in a mouse model of metastatic follicular thyroid carcinoma.

Oncogene - 1 Apr 2010

Zhu X-G, Zhao L, Willingham M C, Cheng S-Y

Abstract excerpt

Aberrant expression and mutations of thyroid hormone receptor genes (TRs) are closely associated with several types of human cancers. To test the hypothesis that TRs could function as tumor suppressors, we took advantage of mice with deletion of all functional TRs (TRalpha1(-/-)TRbeta(-/-) mice). As these mice aged, they spontaneously developed follicular thyroid carcinoma with pathological progression from...

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Share to Adenocarcinoma, Follicular
Share to Cell Proliferation
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Mice, Transgenic

Share to Receptors, Thyroid Hormone

Share to Signal Transduction

Share to Thyroid Neoplasms

Source

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Identifiers

PMID: 20062085
DOI: 10.1038/onc.2009.476
PMCID: PMC3443884

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