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Article

Mice with a Mutation in the Thyroid Hormone Receptor β Gene Spontaneously Develop Thyroid Carcinoma: A Mouse Model of Thyroid Carcinogenesis

1 Nov 2002

Abstract excerpt

The molecular genetic basis of thyroid carcinogenesis is not well understood. Most of the existing models of thyroid cancer only rarely show metastases, and this has limited progress in the understanding of the molecular events in thyroid cancer invasion and metastasis. We have recently generated a mutant mouse by introducing a dominant negative mutant thyroid hormone nuclear receptor gene, TRbetaPV, into the...

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Identifiers

PMID: 12490073
DOI: 10.1089/105072502320908295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mice with a Mutation in the Thyroid Hormone Receptor β Gene Spontaneously Develop Thyroid Carcinoma: A Mouse Model of Thyroid CarcinogenesisPMID 12490073Read ↗

A tumor suppressor role for thyroid hormone beta receptor in a mouse model of thyroid carcinogenesis.Semantic proximity Read ↗

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Regulation of β-Catenin by a Novel Nongenomic Action of Thyroid Hormone β ReceptorSemantic proximity Read ↗

Novel non-genomic signaling of thyroid hormone receptors in thyroid carcinogenesis.Semantic proximity Read ↗

Chromosomal aberrations in cell lines derived from thyroid tumors spontaneously developed in TRbetaPV/PV mice.Semantic proximity Read ↗

Role of TSH in the spontaneous development of asymmetrical thyroid carcinoma in mice with a targeted mutation in a single allele of the thyroid hormone-β receptor.Semantic proximity Read ↗

Marked potentiation of the dominant negative action of a mutant thyroid hormone receptor beta in mice by the ablation of one wild-type beta allele.Semantic proximity Read ↗

Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone.Semantic proximity Read ↗

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An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis.Semantic proximity Read ↗

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