Article
Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.
Cancer research - 15 May 2005
Knauf Jeffrey A, Ma Xiaolan, Smith Eric P, Zhang Lei, Mitsutake Norisato, Liao Xiao-Hui, Refetoff Samuel, Nikiforov Yuri E, Fagin James A
Abstract excerpt
The BRAFT1799A mutation is the most common genetic alteration in papillary thyroid carcinomas (PTC). It is also found in a subset of papillary microcarcinomas, consistent with a role in tumor initiation. PTCs with BRAFT1799A are often invasive and present at a more advanced stage. BRAFT1799A is found with high prevalence in tall-cell variant PTCs and in poorly differentiated and undifferentiated carcinomas...
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