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Article

p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer.

Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2014

McFadden David G, Vernon Amanda, Santiago Philip M, Martinez-McFaline Raul, Bhutkar Arjun, Crowley Denise M, McMahon Martin, Sadow Peter M, Jacks Tyler

Abstract excerpt

Anaplastic thyroid carcinoma (ATC) has among the worst prognoses of any solid malignancy. The low incidence of the disease has in part precluded systematic clinical trials and tissue collection, and there has been little progress in developing effective therapies. v-raf murine sarcoma viral oncogene homolog B (BRAF) and tumor protein p53 (TP53) mutations cooccur in a high proportion of ATCs, particularly those...

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Share to Carcinoma, Papillary
Share to MAP Kinase Signaling System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase Kinases

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Share to Thyroid Carcinoma, Anaplastic

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Source

Open in PubMed Open full text

Identifiers

PMID: 24711431
DOI: 10.1073/pnas.1404357111
PMCID: PMC4000830

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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