Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAF(V600E)-induced thyroid tumors in a mouse model.

Thyroid : official journal of the American Thyroid Association - 1 Mar 2014

Orim Florence, Bychkov Andrey, Shimamura Mika, Nakashima Masahiro, Ito Masahiro, Matsuse Michiko, Kurashige Tomomi, Suzuki Keiji, Saenko Vladimir, Nagayama Yuji, Yamashita Shunichi, Mitsutake Norisato

Abstract excerpt

BACKGROUND: The BRAF(V600E) mutation is the most common genetic alteration in papillary thyroid carcinomas (PTCs). Transgenic mice overexpressing BRAF(V600E) in their thyroids under control of the thyroglobulin promoter (Tg-BRAF2 mice) developed invasive PTCs with high penetrance. However, these mice showed elevated thyrotropin (TSH) levels, which also stimulate the proliferation of thyrocytes and tumorigenesis....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Papillary
Share to Genomic Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Mice, Transgenic

Share to Proto-Oncogene Proteins B-raf

Share to Receptors, Thyrotropin

Share to Thyroid Neoplasms

Share to Thyrotropin

Source

Open in PubMed Open full text

Identifiers

PMID: 23924149
DOI: 10.1089/thy.2013.0038
PMCID: PMC3949501

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAF(V600E)-induced thyroid tumors in a mouse model.PMID 23924149Read ↗

Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.Semantic proximity Read ↗

BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications.Semantic proximity Read ↗

BRAF mutation in thyroid cancer.Semantic proximity Read ↗

BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications.Semantic proximity Read ↗

Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse.Semantic proximity Read ↗

Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in miceSemantic proximity Read ↗

Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis.Semantic proximity Read ↗

BRAFV600E-Associated Gene Expression Profile: Early Changes in the Transcriptome, Based on a Transgenic Mouse Model of Papillary Thyroid CarcinomaSemantic proximity Read ↗

High prevalence of BRAF mutation in a Brazilian cohort of patients with sporadic papillary thyroid carcinomas: correlation with more aggressive phenotype and decreased expression of iodide-metabolizing genes.Semantic proximity Read ↗

p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer.Semantic proximity Read ↗

RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis.Semantic proximity Read ↗

BRAFV600E Overrides NOTCH Signaling in Thyroid Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.