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Article

RET/PTC1-driven neoplastic transformation and proinvasive phenotype of human thyrocytes involve Met induction and beta-catenin nuclear translocation.

Neoplasia (New York, N.Y.) - 1 Jan 2009

Cassinelli Giuliana, Favini Enrica, Degl'Innocenti Debora, Salvi Alessandro, De Petro Giuseppina, Pierotti Marco A, Zunino Franco, Borrello Maria Grazia, Lanzi Cinzia

Abstract excerpt

Activation of the RET gene by chromosomal rearrangements generating RET/PTC oncogenes is a frequent, early, and causative event in papillary thyroid carcinoma (PTC). We have previously shown that, in human primary thyrocytes, RET/PTC1 induces a transcriptional program including the MET proto-oncogene. In PTCs, beta-catenin is frequently mislocated to the cytoplasm nucleus. We investigated the interplay between...

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Identifiers

PMID: 19107227
DOI: 10.1593/neo.08916
PMCID: PMC2606114

Genes

RET
MET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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