RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer.

doi:10.1038/sj.onc.1202381

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Article

RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer.

Oncogene - 24 Sept 1998

Coxon A B, Ward J M, Geradts J, Otterson G A, Zajac-Kaye M, Kaye F J

Abstract excerpt

Mice bred to carry germline Rb and p53 null alleles are associated with a tumor spectrum that overlaps with the inherited multiple endocrine neoplasia-1 (MEN1) and MEN2 syndromes in humans, including medullary thyroid cancer (MTC). To study the genetic basis for these tumors, we microdissected MT...

Topics

Animals
Disease Models, Animal
Drosophila Proteins
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Mice
Multiple Endocrine Neoplasia Type 1
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ret
Receptor Protein-Tyrosine Kinases
Retinoblastoma Protein
Thyroid Neoplasms
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 9794240
DOI: 10.1038/sj.onc.1202381

Genes

MEN1
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9794240-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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