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Article

Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis.

Molecular cancer research : MCR - 1 Jul 2014

Charles Roch-Philippe, Silva Jillian, Iezza Gioia, Phillips Wayne A, McMahon Martin

Abstract excerpt

UNLABELLED: Thyroid malignancies are the most common type of endocrine tumors. Of the various histologic subtypes, anaplastic thyroid carcinoma (ATC) represents a subset of all cases but is responsible for a significant proportion of thyroid cancer-related mortality. Indeed, ATC is regarded as one of the more aggressive and hard to treat forms of cancer. To date, there is a paucity of relevant model systems to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins B-raf

Share to PTEN Phosphohydrolase

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Share to Thyroid Carcinoma, Anaplastic

Source

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Identifiers

PMID: 24770869
DOI: 10.1158/1541-7786.MCR-14-0158-T
PMCID: PMC4635659

Genes

BRAF
PTEN

Variants

Provenance

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