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Article

Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson’s disease: a case control study

24 Apr 2017

Abstract excerpt

Genetic and environmental risk factors play an important role for the susceptibility to sporadic Parkinson’s disease (PD). It was hypothesized that a splice variant of the CYP2D6 gene ( CYP2D6*4 allele) is associated with PD because it alters the ability to metabolize toxins and in particular neurotoxins. CYP2D6 codes for the drug metabolizing enzyme debrisoquine 4-hydroxylase. The CYP2D6*4 variant results in an...

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PMID: 28680508
DOI: 10.1186/s41021-017-0078-8

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