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Article

Cytochrome P4502D6 (debrisoquine 4-hydroxylase) and Parkinson's disease in Chinese and Caucasians.

European journal of neurology - 1 May 1999

Ho S L, Kung M H, Li L S, Lauder I J, Ramsden D B

Abstract excerpt

Four polymorphic sites (C/T188, C/T2938, G/C4268, G/A1934) in the cytochrome P4502D6 (debrisoquine 4-hydroxylase) gene were investigated for their association with sporadic Parkinson's disease (PD). Three mutant alleles (C/T188, C/T2938 and G/C4268) result in amino acid changes which could alter the substrate specificity or alter its ability to metabolize their substrates; the fourth (G/A1934) causes a loss of...

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Identifiers

PMID: 10210913
DOI: 10.1046/j.1468-1331.1999.630323.x

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