Synthesis and assembly of Hepatitis B virus envelope protein-derived particles in Escherichia coli.

doi:10.1016/j.bbrc.2017.06.015

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Article

Synthesis and assembly of Hepatitis B virus envelope protein-derived particles in Escherichia coli.

Biochemical and biophysical research communications - 19 Aug 2017

Li Hao, Onbe Keisuke, Liu Qiushi, Iijima Masumi, Tatematsu Kenji, Seno Masaharu, Tada Hiroko, Kuroda Shun' Ichi

Abstract excerpt

Hepatitis B virus (HBV) envelope particles have been synthesized in eukaryotic cells (e.g., mammalian cells, insect cells, and yeast cells) as an HB vaccine immunogen and drug delivery system (DDS) nanocarrier. Many researchers had made attempts to synthesize the particles in Escherichia coli for minimize the cost and time for producing HBV envelope particles, but the protein was too deleterious to be synthesized...

Topics

Animals
COS Cells
Chlorocebus aethiops
Escherichia coli
Mutation
Particle Size
Viral Envelope Proteins

Source

Open in PubMed

Identifiers

PMID: 28601634
DOI: 10.1016/j.bbrc.2017.06.015

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