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Inhibition of viral replication by genetically engineered mutants of the duck hepatitis B virus core protein.

Hepatology (Baltimore, Md.) - 1 Aug 1996

von Weizsäcker F, Wieland S, Blum H E

Abstract excerpt

The hepatitis B virus (HBV) nucleocapsid consists of 240 viral core proteins that are arranged in a highly symmetrical structure, HBV replication can only take place inside intact nucleocapsids. In the present study, we investigated whether genetically engineered core mutants can inhibit viral replication by interfering with the formation of intact nucleocapsids. Using the duck hepatitis B virus (DHBV) model, a...

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PMID: 8690395
DOI: 10.1002/hep.510240202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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