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Article

Hepatitis C virus envelope glycoproteins complementation patterns and the role of the ecto- and transmembrane domains.

Biochemical and biophysical research communications - 24 Jul 2009

Lin Xiaojing, Zhang Yonghui, Bi Shengli, Lu Jian, Zhao Honglan, Tan Wenjie, Li Dexin, Wang Yue

Abstract excerpt

We separated E1 and E2 of hepatitis C virus (HCV) genotypes 1a, 1b, and 2a into two individual expression plasmids and replaced the transmembrane domains of 1b and 2a E1 and E2 with that of genotype 1a. The complementation features of E1 and E2 as well as the contributions of both the ecto- and transmembrane domains to the formation of the E1E2 complex were evaluated using the HCV pseudoparticle(s) (HCVpp(s))...

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Identifiers

PMID: 19464265
DOI: 10.1016/j.bbrc.2009.05.068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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