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Article

Signal sequences modulate the immunogenic performance of human hepatitis C virus E2 gene.

Molecular immunology - 1 May 2006

Sominskaya Irina, Alekseeva Ekaterina, Skrastina Dace, Mokhonov Vladislav, Starodubova Elizaveta, Jansons Juris, Levi Mikael, Prilipov Alexei, Kozlovska Tatyana, Smirnov Valeri, Pumpens Paul, Isaguliants Maria G

Abstract excerpt

Envelope protein E2 of human hepatitis C virus (HCV) is an attractive component of a prototype HCV vaccine. Delivered by DNA immunogens, E2 evokes specific immune response of Th1-type, failing to induce either considerable antibody production, or T-helper cell proliferation. We aimed at modulating the immunogenic performance of E2 gene by changing the mode of protein expression in eukaryotic cells. Plasmids were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16442623
DOI: 10.1016/j.molimm.2005.11.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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