Article
Hepatitis B virus core gene mutations which block nucleocapsid envelopment.
Journal of virology - 1 Jan 2000
Koschel M, Oed D, Gerelsaikhan T, Thomssen R, Bruss V
Abstract excerpt
Recently we generated a panel of hepatitis B virus core gene mutants carrying single insertions or deletions which allowed efficient expression of the core protein in bacteria and self-assembly of capsids. Eleven of these mutations were introduced into a eukaryotic core gene expression vector and characterized by trans complementation of a core-negative HBV genome in cotransfected human hepatoma HuH7 cells....
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