Article
Three-dimensional structure of the Tn5 synaptic complex transposition intermediate.
Science (New York, N.Y.) - 7 Jul 2000
Davies D R, Goryshin I Y, Reznikoff W S, Rayment I
Abstract excerpt
Genomic evolution has been profoundly influenced by DNA transposition, a process whereby defined DNA segments move freely about the genome. Transposition is mediated by transposases, and similar events are catalyzed by retroviral integrases such as human immunodeficiency virus-1 (HIV-1) integrase. Understanding how these proteins interact with DNA is central to understanding the molecular basis of transposition....
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