Article
Tn5 transposase loops DNA in the absence of Tn5 transposon end sequences.
Molecular microbiology - 1 Dec 2006
Adams Christian D, Schnurr Bernhard, Skoko Dunja, Marko John F, Reznikoff William S
Abstract excerpt
Transposases mediate transposition first by binding specific DNA end sequences that define a transposable element and then by organizing protein and DNA into a highly structured and stable nucleoprotein 'synaptic' complex. Synaptic complex assembly is a central checkpoint in many transposition mechanisms. The Tn5 synaptic complex contains two Tn5 transposase subunits and two Tn5 transposon end sequences, exhibits...
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