Article
Transposase subunit architecture and its relationship to genome size and the rate of transposition in prokaryotes and eukaryotes.
Nucleic acids research - 12 Oct 2018
Blundell-Hunter George, Tellier Michael, Chalmers Ronald
Abstract excerpt
Cut-and-paste transposons are important tools for mutagenesis, gene-delivery and DNA sequencing applications. At the molecular level, the most thoroughly understood are Tn5 and Tn10 in bacteria, and mariner and hAT elements in eukaryotes. All bacterial cut-and-paste transposases characterized to date are monomeric prior to interacting with the transposon end, while all eukaryotic transposases are multimers....
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