Article
Structural role of the flanking DNA in mariner transposon excision.
Nucleic acids research - 27 Feb 2015
Dornan Jacqueline, Grey Heather, Richardson Julia M
Abstract excerpt
During cut-and-paste mariner/Tc1 transposition, transposon DNA is cut precisely at its junction with flanking DNA, ensuring the transposon is neither shortened nor lengthened with each transposition event. Each transposon end is flanked by a TpA dinucleotide: the signature target site duplication of mariner/Tc1 transposition. To establish the role of this sequence in accurate DNA cleavage, we have determined the...
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