Article
Crosstalk between transposase subunits during cleavage of the mariner transposon.
Nucleic acids research - 1 May 2014
Claeys Bouuaert Corentin, Walker Neil, Liu Danxu, Chalmers Ronald
Abstract excerpt
Mariner transposition is a complex reaction that involves three recombination sites and six strand breaking and joining reactions. This requires precise spatial and temporal coordination between the different components to ensure a productive outcome and minimize genomic instability. We have investigated how the cleavage events are orchestrated within the mariner transpososome. We find that cleavage of the...
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