Article
Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression.
The American journal of pathology - 1 Jul 2000
Nagaoka T, Kaburagi Y, Hamaguchi Y, Hasegawa M, Takehara K, Steeber D A, Tedder T F, Sato S
Abstract excerpt
Inflammatory cells play a crucial role in wound healing, but the role of adhesion molecules including L-selectin and intercellular adhesion molecule-1 (ICAM-1) is not known in this process. We examined skin wound repair of excisional wounds in mice lacking L-selectin, ICAM-1, or both. The loss of ICAM-1 inhibited wound healing, keratinocyte migration from the edges of the wound toward the center, and granulation...
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