Article
Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice.
Cell - 13 Aug 1993
Mayadas T N, Johnson R C, Rayburn H, Hynes R O, Wagner D D
Abstract excerpt
P selectin, expressed on surfaces of activated endothelial cells and platelets, is an adhesion receptor for leukocytes. We report that P selectin-deficient mice, generated by gene targeting in embryonic stem cells, exhibit a number of defects in leukocyte behavior, including elevated numbers of c...
Topics
- Alleles
- Animals
- Blood Platelets
- Cell Adhesion Molecules
- Chimera
- E-Selectin
- Embryo, Mammalian
- Endothelium
- Flow Cytometry
- Genotype
- Leukocytes
- Liver
- Lung