Article
Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice.
Cell - 13 Aug 1993
Mayadas T N, Johnson R C, Rayburn H, Hynes R O, Wagner D D
Abstract excerpt
P selectin, expressed on surfaces of activated endothelial cells and platelets, is an adhesion receptor for leukocytes. We report that P selectin-deficient mice, generated by gene targeting in embryonic stem cells, exhibit a number of defects in leukocyte behavior, including elevated numbers of circulating neutrophils, virtually total absence of leukocyte rolling in mesenteric venules, and delayed recruitment of...
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