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Article

ICAM-1: Isoforms and Phenotypes

1 May 2014

Abstract excerpt

ICAM-1 plays an important role in leukocyte trafficking, immunological synapse formation, and numerous cellular immune responses. Although considered a single glycoprotein, there are multiple membrane-bound and soluble ICAM-1 isoforms that arise from alternative splicing and proteolytic cleavage during inflammatory responses. The function and expression of these isoforms on various cell types are poorly...

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PMID: 24795464
DOI: 10.4049/jimmunol.1400135

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