Article
Severe inflammatory defect and reduced viability in CD18 and E-selectin double-mutant mice.
The Journal of clinical investigation - 1 Dec 2000
Forlow S B, White E J, Barlow S C, Feldman S H, Lu H, Bagby G J, Beaudet A L, Bullard D C, Ley K
Abstract excerpt
CD18-deficient mice (CD18(-/-) mice) have a severe leukocyte recruitment defect in some organs, and no detectable defect in other models. Mice lacking E-selectin (CD62E(-/-) mice) have either no defect or a mild defect of neutrophil infiltration, depending on the model. CD18(-/-)CD62E(-/-), but not CD18(-/-)CD62P(-/-), mice generated by crossbreeding failed to thrive, reaching a maximum body weight of 10-15...
Topics
- Animals
- Body Weight
- Bone Marrow Cells
- Bone Marrow Transplantation
- CD18 Antigens
- Cell Adhesion
- Chemotaxis, Leukocyte
- E-Selectin
- Failure to Thrive
- Female
- Gene Deletion
- Granulocyte Colony-Stimulating Factor
- Granulocyte-Macrophage Colony-Stimulating Factor