Severely reduced neutrophil adhesion and impaired host defense against fecal and commensal bacteria in CD18-/-P-selectin-/- double null mice.

doi:10.1096/fj.02-0230com

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Article

Severely reduced neutrophil adhesion and impaired host defense against fecal and commensal bacteria in CD18-/-P-selectin-/- double null mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2002

Forlow Stephen Bradley, Foley Patricia L, Ley Klaus

Abstract excerpt

Leukocyte recruitment to sites of inflammation requires the functions of selectins and integrins. P-selectin null (CD62P-/-) mice show a mild and CD18 null (CD18-/-) mice a more severe neutrophil recruitment defect in some inflammatory models. To investigate the possible cooperative interactions between CD18 integrins and P-selectin in mediating neutrophil recruitment, we generated CD18-/-CD62P-/- double null...

Topics

Animals
Bacteria
Bacterial Infections
Body Weight
CD18 Antigens
Cell Adhesion
Escherichia coli
Feces
Female
Immunity, Innate
Lactobacillus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocyte Rolling

Liver

Lung

Male

Mice

Mice, Inbred C57BL

Mice, Knockout

Source

Open in PubMed

Identifiers

PMID: 12374771
DOI: 10.1096/fj.02-0230com

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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