Article
Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment.
Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 1999
Robinson S D, Frenette P S, Rayburn H, Cummiskey M, Ullman-Culleré M, Wagner D D, Hynes R O
Abstract excerpt
We extend our previous analyses of mice deficient in selectins by describing the generation and comparative phenotype of mice lacking one, two, or three selectins after sequential ablation of the murine genes encoding P-, E-, and L-selectins. All mice deficient in selectins are viable and fertile as homozygotes. However, mice missing both P- and E-selectins (PE(-/-)), and mice missing all three selectins...
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