Article
Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice.
Immunity - 1 Jul 1994
Arbonés M L, Ord D C, Ley K, Ratech H, Maynard-Curry C, Otten G, Capon D J, Tedder T F
Abstract excerpt
L-selectin, a cell adhesion molecule expressed by leukocytes, mediates the attachment of lymphocytes to high endothelial venules (HEV) of peripheral lymph nodes and mediates the earliest interactions between leukocytes and activated vascular endothelium. Mice possessing a mutant L-selectin gene that results in the complete loss of cell surface receptor expression were generated by gene targeting. Lymphocytes from...
Topics
- Animals
- Cell Adhesion Molecules
- Cell Movement
- Gene Targeting
- In Vitro Techniques
- L-Selectin
- Leukocytes
- Lymph Nodes
- Lymphocytes
- Mice
- Mice, Mutant Strains