Article
Impaired wound contraction in stromelysin-1-deficient mice.
Annals of surgery - 1 Aug 1999
Bullard K M, Lund L, Mudgett J S, Mellin T N, Hunt T K, Murphy B, Ronan J, Werb Z, Banda M J
Abstract excerpt
OBJECTIVE: To determine whether the deletion of stromelysin-1, a single metalloproteinase gene product, will alter the time course and quality of dermal wound repair in mice. SUMMARY BACKGROUND DATA: After dermal injury, a highly coordinated program of events is initiated by formation of a fibrin clot, followed by migration of keratinocytes, contraction of the dermis, recruitment of inflammatory macrophages,...
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