Article
PCR-generated padlock probes detect single nucleotide variation in genomic DNA.
Nucleic acids research - 15 Jun 2000
Antson D O, Isaksson A, Landegren U, Nilsson M
Abstract excerpt
Circularizing oligonucleotide probes, so-called padlock probes, have properties that should prove valuable in a wide range of genetic investigations, including in situ analyses, genotyping and measurement of gene expression. However, padlock probes can be difficult to obtain by standard oligonucleotide synthesis because they are relatively long and require intact 5'- and 3'-end sequences to function. We describe...
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