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Article

Amplification of padlock probes for DNA diagnostics by cascade rolling circle amplification or the polymerase chain reaction.

Archives of pathology & laboratory medicine - 1 Dec 1999

Thomas D C, Nardone G A, Randall S K

Abstract excerpt

CONTEXT: Padlock probes are highly specific reagents for DNA diagnostics that can discriminate gene sequences with single base mutations. When the 3' and 5' terminal regions of the oligonucleotide probes are juxtaposed on a target DNA sequence, they can be circularized by enzymatic ligation and become topologically locked to the target. However, to be useful in solution-based diagnostics, the sensitivity of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10583921
DOI: 10.1043/1543-2165-123.20.1170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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