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Article

Lock and roll: single-molecule genotyping in situ using padlock probes and rolling-circle amplification.

Histochemistry and cell biology - 1 Aug 2006

Nilsson Mats

Abstract excerpt

In this review I will describe the development of a technique that enables genotyping of individual DNA molecules in the context of morphologically preserved fixed cells, from the fundamental concept published in 1994 to the present status. The review describes enzyme-assisted histochemistry approaches to achieve highly specific molecular identification reactions coupled to efficient signal amplification. The...

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PMID: 16807721
DOI: 10.1007/s00418-006-0213-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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