Article
Amplification of circularizable probes for the detection of target nucleic acids and proteins.
Clinica chimica acta; international journal of clinical chemistry - 1 Jan 2006
Zhang David, Wu Josephine, Ye Fei, Feng Tao, Lee Ivy, Yin Bingjiao
Abstract excerpt
BACKGROUND: Circularizable oligonucleotide probe (C-probe) is a unique molecule that offers significant advantages over conventional probes. METHODS: Closed circular structure can be formed through ligation of the juxtaposed ends of the C-probe after hybridization with a target, and subsequently locked onto its target through the helical turns formed between the complementary sequences of the target and the...
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