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Padlock Probes: Circularizing Oligonucleotides for Localized DNA Detection

30 Sept 1994

Abstract excerpt

Nucleotide sequence information derived from DNA segments of the human and other genomes is accumulating rapidly. However, it frequently proves difficult to use such short DNA segments to identify clones in genomic libraries or fragments in blots of the whole genome or for in situ analysis of chromosomes. Oligonucleotide probes, consisting of two target-complementary segments, connected by a linker sequence, were...

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PMID: 7522346
DOI: 10.1126/science.7522346

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