Article
Linkage of the CCR5 Delta 32 mutation with a functional polymorphism of CD45RA.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2000
Liao H X, Montefiori D C, Patel D D, Lee D M, Scott W K, Pericak-Vance M, Haynes B F
Abstract excerpt
A 32-bp deletion in CCR5 (CCR5 Delta 32) confers to PBMC resistance to HIV-1 isolates that use CCR5 as a coreceptor. To study this mutation in T cell development, we have screened 571 human thymus tissues for the mutation. We identified 72 thymuses (12.6%) that were heterozygous and 2 (0.35%) that were homozygous for the CCR5 Delta 32 mutation. We found that thymocyte development was normal in both CCR5 Delta 32...
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