Article
Genotype and allele frequency of a 32-base pair deletion mutation in the CCR5 gene in various ethnic groups: absence of mutation among Asians and Pacific Islanders.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Jan 1999
Lu Y, Nerurkar V R, Dashwood W M, Woodward C L, Ablan S, Shikuma C M, Grandinetti A, Chang H, Nguyen H T, Wu Z, Yamamura Y, Boto W O, Merriwether A, Kurata T, Detels R, Yanagihara R
Abstract excerpt
BACKGROUND: A 32-base pair (bp) deletion mutation in the beta-chemokine receptor CCR5 gene has been associated with resistance against human immunodeficiency virus type 1 (HIV-1) infection and disease. Large-scale studies conducted among Caucasians indicate that individuals who are homozygous for this deletion mutation (D32/D32) are protected against HIV-1 infection despite multiple high-risk exposures, whereas...
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