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Article

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.

Genes & development - 15 Jun 2000

Takai H, Tominaga K, Motoyama N, Minamishima Y A, Nagahama H, Tsukiyama T, Ikeda K, Nakayama K, Nakanishi M, Nakayama K

Abstract excerpt

The recent discovery of checkpoint kinases has suggested the conservation of checkpoint mechanisms between yeast and mammals. In yeast, the protein kinase Chk1 is thought to mediate signaling associated with the DNA damage checkpoint of the cell cycle. However, the function of Chk1 in mammals has remained unknown. Targeted disruption of Chk1 in mice showed that Chk1(-/-) embryos exhibit gross morphologic...

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Identifiers

PMID: 10859163
PMCID: PMC316691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.PMID 10859163Read ↗

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