Chk1 is haploinsufficient for multiple functions critical to tumor suppression.

doi:10.1016/j.ccr.2004.06.015

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Chk1 is haploinsufficient for multiple functions critical to tumor suppression.

Cancer cell - 1 Jul 2004

Lam Michael H, Liu Qinghua, Elledge Stephen J, Rosen Jeffrey M

Abstract excerpt

The haploinsufficient tumor suppressor Chk1 is essential for embryonic cells, but the consequences of Chk1 loss in adult tissues are unknown. Using conditional Chk1 mice, we find that proliferating mammary cells lacking Chk1 undergo apoptosis leading to developmental defects. Conditional Chk1 heterozygosity increased the number of S phase cells and caused spontaneous DNA damage. Chk1+/- epithelia also exhibit a...

Topics

Animals
Apoptosis
Checkpoint Kinase 1
DNA Damage
DNA Replication
Epithelial Cells
Genes, Tumor Suppressor
Integrases
Mammary Glands, Animal
Mice
Mice, Knockout
Microfilament Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitosis

Muscle Proteins

Phenotype

Protein Kinases

S Phase

Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 15261141
DOI: 10.1016/j.ccr.2004.06.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chk1 is haploinsufficient for multiple functions critical to tumor suppression.PMID 15261141Read ↗

Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells.Semantic proximity Read ↗

Specific role of Chk1 phosphorylations in cell survival and checkpoint activation.Semantic proximity Read ↗

Nuclear Chk1 prevents premature mitotic entry.Semantic proximity Read ↗

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.Semantic proximity Read ↗

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.Semantic proximity Read ↗

Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cellsSemantic proximity Read ↗

Chk1 and Chk2 kinases in checkpoint control and cancer.Semantic proximity Read ↗

Ras–MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer CellsSemantic proximity Read ↗

Unleashing Chk1 in cancer therapySemantic proximity Read ↗

PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in cells.Semantic proximity Read ↗

When more is less: heritable gain-of-function chk1 mutations impair human fertility.Semantic proximity Read ↗

U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.