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Article

Checkpoint kinase 1 is essential for fetal and adult hematopoiesis

17 Jun 2019

Abstract excerpt

Checkpoint kinase 1 (CHK1) is critical for S-phase fidelity and preventing premature mitotic entry in the presence of DNA damage. Tumor cells have developed a strong dependence on CHK1 for survival, and hence, this kinase has developed into a promising drug target. Chk1 deficiency in mice results in blastocyst death due to G2/M checkpoint failure showing that it is an essential gene and may be difficult to target...

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Share to Acute Myeloid Leukemia Research
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PMID: 31379128
DOI: 10.15252/embr.201847026

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