Article

Checkpoint kinase 1 is essential for establishing fetal haematopoiesis and hematopoietic stem and progenitor cell survival

2018-09-10

Abstract excerpt

<h4>ABSTRACT</h4> Checkpoint kinase 1 is critical for S-phase fidelity and preventing premature mitotic entry in the presence of DNA damage. Tumour cells have developed a strong dependence on CHK1 for survival and hence this kinase has developed into a popular drug-target. Chk1 -deficiency in mice results in blastocyst death due to G2/M checkpoint-failure showing that it is an essential gene and may be difficult...

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Literature Corpus work: fb32df53-180f-5abc-b136-b2312c705ff4
DOI: 10.1101/413310

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