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Article

U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint.

Journal of cellular and molecular medicine - 1 Aug 2009

Carrassa Laura, Sanchez Yolanda, Erba Eugenio, Damia Giovanna

Abstract excerpt

Chk1 is a conserved protein kinase originally identified in fission yeast, required to delay entry of cells with damaged or unreplicated DNA into mitosis. The requirement of Chk1 for both S and G2/M checkpoints has been elucidated while only few studies have connected Chk1 to the mitotic spindle checkpoint. We used a small interference RNA strategy to investigate the role of Chk1 in unstressed conditions. Chk1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19778378
DOI: 10.1111/j.1582-4934.2009.00362.x
PMCID: PMC3828867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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