Article
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.
Science (New York, N.Y.) - 5 Nov 1999
Sanchez Y, Bachant J, Wang H, Hu F, Liu D, Tetzlaff M, Elledge S J
Abstract excerpt
In response to DNA damage, cells activate checkpoint pathways that prevent cell cycle progression. In fission yeast and mammals, mitotic arrest in response to DNA damage requires inhibitory Cdk phosphorylation regulated by Chk1. This study indicates that Chk1 is required for function of the DNA damage checkpoint in Saccharomyces cerevisiae but acts through a distinct mechanism maintaining the abundance of Pds1,...
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