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Article

Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2007

Zaugg Kathrin, Su Yu-Wen, Reilly Patrick T, Moolani Yasmin, Cheung Carol C, Hakem Razquallah, Hirao Atsushi, Liu Qinghua, Elledge Stephen J, Mak Tak W

Abstract excerpt

Chk1 is a checkpoint kinase and an important regulator of mammalian cell division. Because null mutation of Chk1 in mice is embryonic lethal, we used the Cre-loxP system and the Lck promoter to generate conditional mutant mice in which Chk1 was deleted only in the T lineage. In the absence of Chk1, the transition of CD4(-)CD8(-) double-negative (DN) thymocytes to CD4(+)CD8(+) double-positive (DP) cells was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17360434
DOI: 10.1073/pnas.0611584104
PMCID: PMC1820665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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