Article

CHK1-CDC25A-CDK1 regulate cell cycle progression in early mouse embryos to protect genome integrity

2022-11-14

Abstract excerpt

<h4>ABSTRACT</h4> After fertilization, remodeling of the oocyte and sperm genomes is essential to convert these highly differentiated non-dividing transcriptionally quiescent cells into early cleavage-stage transcriptionally active totipotent blastomeres. This developmental transition is accompanied by cell cycle adaptation such as lengthening or shortening of the gap phases G1 and G2. However, regulation of thes...

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Literature Corpus work: 127e9a3a-940e-5a78-8f79-c89dbaefb3ce
DOI: 10.1101/2022.11.13.516318

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