Article
TNF gene polymorphism and its relation to intracerebral production of TNFalpha and TNFbeta in AD.
Neurology - 13 Jun 2000
Tarkowski E, Liljeroth A M, Nilsson A, Ricksten A, Davidsson P, Minthon L, Blennow K
Abstract excerpt
OBJECTIVE: To analyze the extent of tumor necrosis factor-alpha (TNFalpha) and TNFbeta gene polymorphism in patients with AD and to relate it to intrathecal levels of these cytokines. METHODS: Analyses of TNFalpha and TNFbeta gene polymorphism were performed using PCR in 52 patients with AD and in 25 control subjects, and the levels of corresponding cytokines were analyzed using ELISA. RESULTS: Patients with AD...
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