IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer's Disease Pathology.

doi:10.3233/JAD-200056

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Article

IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer's Disease Pathology.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Babić Leko Mirjana, Nikolac Perković Matea, Klepac Nataša, Štrac Dubravka Švob, Borovečki Fran, Pivac Nela, Hof Patrick R, Šimić Goran

Abstract excerpt

BACKGROUND: Neuroinflammation plays an important role in Alzheimer's disease (AD). During this process, activated microglia release pro-inflammatory cytokines such as interleukin (IL)-1α, IL-1β, IL-6, and tumor necrosis factor α (TNFα) that participate in neuron damage, but also anti-inflammatory cytokines (such as IL-10), which maintain homeostasis of immune response. Previous studies showed the association of...

Topics

Aged
Alzheimer Disease
Amyloid beta-Peptides
Biomarkers
Encephalitis
Female
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-1beta

Interleukin-6

Male

Middle Aged

Polymorphism, Single Nucleotide

Tumor Necrosis Factor-alpha

tau Proteins

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Open in PubMed

Identifiers

PMID: 32390629
DOI: 10.3233/JAD-200056

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