Article
Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia: a case-control study.
Lancet (London, England) - 10 Feb 2001
McCusker S M, Curran M D, Dynan K B, McCullagh C D, Urquhart D D, Middleton D, Patterson C C, McIlroy S P, Passmore A P
Abstract excerpt
BACKGROUND: Deposition of beta-amyloid in the brains of patients with Alzheimer's disease is thought to precede a chain of events that leads to an inflammatory response by the brain. We postulated that genetic variation in the regulatory region of the gene for the proinflammatory cytokine tumour...
Topics
- Aged
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Case-Control Studies
- Dementia, Multi-Infarct
- Dementia, Vascular
- Female
- Genes, Regulator
- Genetic Carrier Screening
- Genetic Predisposition to Disease