Article
Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia: a case-control study.
Lancet (London, England) - 10 Feb 2001
McCusker S M, Curran M D, Dynan K B, McCullagh C D, Urquhart D D, Middleton D, Patterson C C, McIlroy S P, Passmore A P
Abstract excerpt
BACKGROUND: Deposition of beta-amyloid in the brains of patients with Alzheimer's disease is thought to precede a chain of events that leads to an inflammatory response by the brain. We postulated that genetic variation in the regulatory region of the gene for the proinflammatory cytokine tumour necrosis factor alpha (TNF-alpha) leads to increased risk of Alzheimer's disease and vascular dementia. METHODS: A...
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