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Article

Molecular pathology in the obese spontaneous hypertensive Koletsky rat: a model of syndrome X.

Annals of the New York Academy of Sciences - 18 Nov 1999

Ernsberger P, Koletsky R J, Friedman J E

Abstract excerpt

The SHROB rat is a unique strain with genetic obesity, hypertriglyceridemia, hyperinsulinemia, renal disease with proteinuria, and genetically determined hypertension, characteristics paralleling human Syndrome X. The obese phenotype results from a single homozygous recessive trait, designated faK, and is allelic with the Zucker fatty trait (fa), but of distinct origin. The faK mutation is a premature stop codon...

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Identifiers

PMID: 10842668
DOI: 10.1111/j.1749-6632.1999.tb07801.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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