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The BBZDR/Wor Rat Model for Investigating the Complications of Type 2 Diabetes Mellitus

1 Jan 2004

Abstract excerpt

Congenic and inbred strains of rats offer researchers invaluable insight into the etiopathogenesis of diabetes and associated complications. The inbred Bio-Breeding Zucker diabetic rat (BBZDR)/Wor rat strain is a relatively new and emerging model of type 2 diabetes. This strain was created by classical breeding methods used to introgress the defective leptin receptor gene (Lepr(fa)) from insulin-resistant Zucker...

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PMID: 15229376
DOI: 10.1093/ilar.45.3.292

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