Article
Urotensin II receptor knockout mice on an ApoE knockout background fed a high-fat diet exhibit an enhanced hyperlipidemic and atherosclerotic phenotype.
Circulation research - 25 Sept 2009
Bousette Nicolas, D'Orleans-Juste Pedro, Kiss Robert S, You Zhipeng, Genest Jacques, Al-Ramli Wisam, Qureshi Salman T, Gramolini Anthony, Behm David, Ohlstein Eliot H, Harrison Stephen M, Douglas Stephen A, Giaid Adel
Abstract excerpt
RATIONALE: Expression of the vasoactive peptide Urotensin II (UII) is elevated in a number of cardiovascular diseases. OBJECTIVE: Here, we sought to determine the effect of UII receptor (UT) gene deletion in a mouse model of atherosclerosis. METHODS AND RESULTS: UT knockout (KO) mice were crossed with ApoE KO mice to generate UT/ApoE double knockout (DKO) mice. Mice were placed on a high-fat Western-type diet for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.